A working list of startups operating in the commonwealth, with ecosystem organizations available as separate views. Search, sort, filter — submit additions anytime.
56 of 466
#Company↑SectorStageFoundedDescriptionRegion
001
Acumen Pharmaceuticals
Pharmaceutical company focused on developing treatments.
Biotech—1996Pharmaceutical company focused on developing treatments.CVL→
002
AgroSpheres
AgBiotech developing novel delivery system for safer, more effective pesticide delivery using Minicell bioparticle technology. 25+ employees.
BiotechSeries B2016AgBiotech developing novel delivery system for safer, more effective pesticide delivery using Minicell bioparticle technology. 25+ employees.CVL→
003
Apex Clean Energy
Develops, constructs, and operates utility-scale wind, solar, and storage facilities. Mission to accelerate shift to clean energy. 400+ employees.
ClimateSeries B2009Develops, constructs, and operates utility-scale wind, solar, and storage facilities. Mission to accelerate shift to clean energy. 400+ employees.CVL→
004
Astraea
EarthAI machine-learning platform for satellite/geospatial data.
AISeries A2016EarthAI machine-learning platform for satellite/geospatial data.CVL→
005
Brightspec, Inc.
Brightspec, Inc. is a Charlottesville, Virginia-based speciality chemicals company.
Materials—2012Brightspec, Inc. is a Charlottesville, Virginia-based speciality chemicals company.CVL→
006
BUILT Biotechnologies
Regenerative DNA Assembly process for DNA synthesis and manufacturing-as-a-service.
BiotechSeed2021Regenerative DNA Assembly process for DNA synthesis and manufacturing-as-a-service.CVL→
007
Caretaker Medical
Develops wireless medical devices for ICU-quality remote patient monitoring. Multiple FDA clearances for VitalStream product.
Health—2014Develops wireless medical devices for ICU-quality remote patient monitoring. Multiple FDA clearances for VitalStream product.CVL→
008
CAV Angels
Charlottesville angel network supporting startups connected to the University of Virginia community.
CapitalCapital2014Charlottesville angel network supporting startups connected to the University of Virginia community.CVL→
009
Center for Open Science
Non-profit technology organization promoting open science practices.
Software——Non-profit technology organization promoting open science practices.CVL→
010
Cerillo, Llc
Cerillo, Llc is a Charlottesville, Virginia-based company.
Biotech—2016Cerillo, Llc is a Charlottesville, Virginia-based company.CVL→
011
Charlottesville Angel Network
Charlottesville area angel network with over $20 million invested in nearly 80 startups.
CapitalCapital2015Charlottesville area angel network with over $20 million invested in nearly 80 startups.CVL→
012
ChartIQ
ChartIQ is a Charlottesville, Virginia-based company.
Fintech—2012ChartIQ is a Charlottesville, Virginia-based company.CVL→
013
CloudFit Software
CloudFit Software offers managed IT services and cybersecurity solutions for businesses, specializing in mission-critical workloads for government and defense.
Cybersecurity—2018CloudFit Software offers managed IT services and cybersecurity solutions for businesses, specializing in mission-critical workloads for government and defense.CVL→
014
Contraline
Revolutionizing contraception with first long-lasting, reversible option for men.
HealthSeries B2015Revolutionizing contraception with first long-lasting, reversible option for men.CVL→
015
Cosaic
Technology company (details from source limited).
Software——Technology company (details from source limited).CVL→
016
CounterFlow AI
CounterFlow AI is an Artificial Intelligence start-up developing a network forensics platform for threat hunting.
AI——CounterFlow AI is an Artificial Intelligence start-up developing a network forensics platform for threat hunting.CVL→
017
CvilleBioHub member: Diffuse Bio
Generative AI for protein and small-molecule design.
BiotechPre-seed2023Generative AI for protein and small-molecule design.CVL→
018
Everactive
Everactive provides a hardware toolkit and managed network purpose-built for self-powered devices.
Industrial——Everactive provides a hardware toolkit and managed network purpose-built for self-powered devices.CVL→
019
Fermata Energy
Nation's leader in proven V2X systems. Designs bidirectional EV chargers that integrate electric vehicles with buildings and electricity grid.
Automotive—2010Nation's leader in proven V2X systems. Designs bidirectional EV chargers that integrate electric vehicles with buildings and electricity grid.CVL→
020
HemoShear Therapeutics
Human-relevant disease models for rare metabolic diseases and pharma partnerships.
BiotechSeries B2008Human-relevant disease models for rare metabolic diseases and pharma partnerships.CVL→
021
HemoSonics
HemoSonics is a Charlottesville, Virginia-based medical device company developing tools and supplies for in vitro diagnostics.
Health——HemoSonics is a Charlottesville, Virginia-based medical device company developing tools and supplies for in vitro diagnostics.CVL→
022
Hyperion Bio
Single-cell sequencing instruments and reagents (UVA spinout).
BiotechSeed2022Single-cell sequencing instruments and reagents (UVA spinout).CVL→
023
Laser Thermal Analysis
Steady-state thermoreflectance instruments for materials thermal analysis.
MaterialsSeed2018Steady-state thermoreflectance instruments for materials thermal analysis.CVL→
024
Lithium Technologies
Lithium Technologies is an IT startup based in Lynchburg.
Manufacturing—2022Lithium Technologies is an IT startup based in Lynchburg.CVL→
025
Lumacyte
Lumacyte is a Virginia-based company focusing on rapid label-free single cell analysis.
Biotech——Lumacyte is a Virginia-based company focusing on rapid label-free single cell analysis.CVL→